Molecules / Principles

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  • NMDA Receptor (NMDA Receptor): The NMDA receptor is a type of ionotropic glutamate receptor that plays a critical role in synaptic plasticity, as it requires both the binding of glutamate and sufficient postsynaptic depolarization to open its channel and allow calcium influx.
  • AMPA Receptor (AMPA Receptor): The AMPA receptor is an ionotropic glutamate receptor that mediates fast excitatory synaptic transmission in the central nervous system, opening rapidly when glutamate binds to allow sodium influx and cause depolarization.
  • Hebbian Learning (Hebbian Learning): Hebbian learning is a principle summarized by the phrase "cells that fire together, wire together," proposing that when an axon of cell A is near enough to excite cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A's efficiency, as one of the cells firing B, is increased.